| • Tanaka, S.†, Kawakita, M.†, Yasui, H., Sudo, K., Itoh, F., Sasaki, M., Shibata, N., Hara, H., Iwakura, Y., Hashidate-Yoshida, T., Shindou, H., Shimizu, T., Oyama, T., Matsunaga, H. and Takahara, K., An immune-adrenergic pathway induces lethal levels of platelet-activating factor in mice. Commun. Biol. (2024) (in press, †equal contribution)
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• Sudo, K., Todoroki, T., Ka, Y., and Takahara, K., Vg5Vd1 TCR signaling is required to different extents for embryonic versus postnatal development of DETCs. Int. Immunol., 34, 263–276 (2022). (Selected as Featured article of the month/Editor's Choice, and Highlights from International Immunology in 2022)
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• Kawakita, M., Oyama, T., Shirai, I., Tanaka, S., Akaki, K., Abe, S., Asahi, T, Cui, G., Itoh, F., Sasaki, M., Shibata, N., Ikuta, K., Hatakeyama, T. and Takahara, K., Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis. Commun. Biol. DOI: 10.1038/s42003-021-01870-3 (2021).
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• Cui, G., Shimba, A., Ma, G, Takahara, K., Tani-ichi, S., Zhu, Y., Asahi, T., Abe, A., Miyachi, H., Kitano, S., Hara, T., Yasunaga, J., Suwanai, H., Yamada, H., Matsuoka, M., Ueki, K., Yoshikai, Y, and Ikuta, K. IL-7R-dependent Phosphatidylinositol-3 Kinase Competes with STAT5 Signal to Modulate T Cell Development and Homeostasis. J. Immunol. 204, 844-57 (2020).
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• Goji, T., Takahara, K., Negishi, M. and Katoh, H. Glucose metabolism in glioblastoma cells protects against cell death triggered by cystine uptake through xCT. J. Biol. Chem. 292, 19721–19732 (2017).
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• Ishiguro, T.†, Fukawa, T.†, Akaki, K., Nagaoka, K., Takeda, T., Iwakura, Y., Inaba, K., and Takahara, K. Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice. Eur. J. Immunol. 47, 704-12 (2017) (†equal contribution)
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• Tokieda, S., Komori, M., Ishiguro, Iwakura, Y., Takahara, K.* and Inaba, K. Dendritic cell immunoreceptor 1 alters neutrophil responses in the development of experimental colitis. BMC Immunol. 16, 64 (2015) (*corresponding author)
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• Ushida, M., Iyoda, T., Kanamori, M., Watarai, H., Takahara, K.* and Inaba, K. In vivo and in vitro analyses of α-galactosylceramide uptake by conventional dendritic cell subsets using its fluorescence-labeled derivative. Immunol. Lett. 168, 300-5 (2015) (*corresponding author)
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• Taneo, J., Adachi, T, Yoshida, A., Takeyasu, K., Takahara, K.* and Inaba, K. Amyloid β oligomers induce interleukin-1β production in primary microglia in a cathepsin B- and reactive oxygen species-dependent manner. Biochem. Biophys. Res. Commun. 458, 561-7 (2015) (*corresponding author)
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• Adachi, T., Takahara, K., Taneo, J., Uchiyama, Y. and Inaba, K. Particle size of latex beads dictates IL-1β production mechanism. Plos One 8, e68499 (2013)
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• Minamino, K., Takahara, K., Adachi, T., Nagaoka, K., Iyoda, T., Taki, S., and Inaba, K. IRF-2 regulates B cell proliferation and antibody production through distinct mechanisms. Int. Immunol. 24, 573-81 (2012)
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• Takahara, K., Arita, T., Tokieda, S., Shibata, N., Okawa, Y., Tateno, H., Hirabayashi, J. and Inaba, K. Difference in fine specificity to polysaccharides of C. albicans mannoprotein between mouse SIGNR1 and human DC-SIGN. Infect. Immun. 89, 1699-1706 (2012)
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• Takahara, K., Tokieda, S., Nagaoka, K. and Inaba, K. Efficient capture of C. albicans and zymosan by SIGNR1 facilitates TLR2-dependent TNF-α production by macrophages. Int. Immunol. 24, 89-96 (2012)
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• Kobayashi, C., Shiina, T., Tokioka, A., Hattori, Y., Komori, T., Kobayashi-Miura, M., Takizawa, T., Takahara, K., Inaba, K., Inoko, H., Takeya, M., Dranoff, G. and Sugita, M. GM-CSF-independent CD1a expression in epidermal Langerhans cells: evidence from human CD1A genome-transgenic mice. J. Invest. Dermatol. 132, 241-244 (2012)
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• Takahara, K., Tokieda, S., Nagaoka, K., Takeda, T., Kimura, Y. and Inaba, K. C-type lectin SIGNR1 enhances cellular oxidative burst response against C. albicans in cooperation with Dectin-1. Eur. J. Immunol. 41, 1435-44 (2011)
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• Nagaoka, K., Takahara, K., Minamino, K., Takeda, T., Yoshida, Y. and Inaba, K. Expression of C-type lectin, SIGNR3, on subsets of dendritic cells, macrophages and monocytes. J. Leukoc. Biol. 88, 913-924 (2010)
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• Shin, D. M., Yang, C. S., Yuk. J. M., Lee, J. Y., Kim, K. H., Shin, S. J., Takahara, K., Lee, S.J. and Jo, E. K. Mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1. Cell. Microbiol., 10, 1608-1621 (2008)
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• Nagaoka, K.†, Takahara, K.†, Tanaka, K., Yoshida, H., Steinman, R. M., Saitoh, S., Akashi-Takamura, S., Miyake, K., Kang, Y. S., Park, C. G. and Inaba, K. Association of SIGNR1 with TLR4/MD-2 enhances signal transduction by recognition of LPS in Gram-negative bacteria. Int. Immunol. 17, 827-836 (2005) (†equal contribution).
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• Takahara, K.†, Yashima, Y.†, Yoshida, H, Kimura, Y, Kang, Y.-S., Steinman, R. M., Park, C. G. and Inaba, K. Functional comparison of the mouse DC-SIGN, SIGNR1, SIGNR3 and Langerin, C-type lectins. Int. Immunol. 16, 819-829 (2004) (†equal contribution).
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• Ichikawa, E., Hida, S., Omatsu, Y., Shimoyama, S., Takahara, K., Miyagawa. S., Inaba, K. and Taki, S. Defective development of splenic and epidermal CD4+ dendritic cells in mice deficient for IFN regulatory factor-2. Proc. Natl. Acad. Sci. U.S.A. 101, 3909-3914 (2004)
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• Wang, W. -M., Lee, S., Steiglitz, B. M., Scott, I. C., Lebares, C.C., Allen, L, Brenner, M. C., Takahara, K. and Greenspan, D. S. Transforming growth factor-β induces secretion of activated ADAMTS-2: A procollagen III N-proteinase. J. Biol. Chem. 278, 19549-19557 (2003)
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• Kang, Y.-S.†, Yamazaki, S.†, Iyoda, T.†, Pack, M., Bruening, S. A., Kim, J. Y., Takahara, K., Inaba, K., Steinman, R. M. and Park, C. G. SIGN-R1, a novel C-type lectin expressed by marginal zone macrophages in spleen, mediates uptake of the polysaccharide dextran. Int. Immunol. 15, 177-186 (2003) (†equal contribution).
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• Ichioka, N., Inaba, M., Kushida, T., Esumi, T., Takahara, K., Inaba., K., Ogawa, R., Iida, H. and Ikehara, S. Prevention of senile osteoporosis in SAMP6 mice by intra-bone marrow injection of allogeneic bone marrow cells. Stem Cells 20, 542-551 (2002)
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• Takahara, K.†, Schwarze, U.†, Imamura, Y., Hoffman, G. G., Toriello, H., Smith, L. T., Byers, P. H. and Greenspan, D. S. Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor site mutation that results in abnormal pro-α1(V) N-propeptides and Ehlers-Danlos syndrome type I. Amer. J. Human Genetics 71, 451-465 (2002) (†equal contribution)
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• Iyoda, T., Shimoyama, S., Liu, K., Omatsu, Y., Akiyama, Y., Maeda, Y., Takahara, K., Steinman,R. M. and Inaba. K. The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo. J. Exp. Med. 195, 1289-1302 (2002)
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• Ligon, A. H., Scott, I. C., Takahara, K., Greenspan, D. S. and Morton, C. C. PCOLCE deletion and expression analysis in uterine leiomyomata. Cancer Genet. Cytogenet. 137, 133-137 (2002)
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•Takahara, K., Omatsu, Y, Yashima, Y., Yasuhiro, M., Tanaka, S., Iyoda, T., Clausen, B., Matsubara, K., Letterio, J., Steinman, R. M., Matsuda, Y. and Inaba, K. Identification and expression of mouse Langerin (CD207) in dendritic cells. Int. Immunol. 14, 433-444 (2002)
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•Park, C. G.†, Takahara, K.†, Umemoto, E., Yashima, Y., Matsubara, K., Matsuda, Y., Clausen, B. E., Inaba, K. and Steinman, R. M. Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN. Int. Immunol. 13, 1283-1290 (2001) (†equal contribution)
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• Komuro, H., Mori, M., Hayashi, Y., Fukagawa, M., Makino, S., Takahara, K., Greenspan, D. S. and Momoi, M. Lack of BMP-1 gene mutations in patient with gastroschisis. J. Pediatric Surgery 36, 885-887 (2001)
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• Amano, S., Scott , I. C., Takahara, K., Koch, M., Gerecke, D. R., Keene, D. R., Hudson, D. L., Nishiyama, T., Lee, S., Greenspan, D. S. and Burgeson R. E. Bone morphogenetic protein 1 (BMP-1) is an extracellular processing enzyme of the laminin 5γ2 chain. J. Biol. Chem. 275, 22728 -22735 (2000)
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• Mott, J. D., Thomas, C. L., Rosenbach, M. T., Takahara, K., Greenspan, D. S. and Banda, M. J. Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer release a metalloproteinase inhibitor. J. Biol. Chem. 275, 1384-1390 (2000)
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• Scott, I. C., Blitz, I. L., Pappano, W. N., Imamura, Y., Clark, T. G., Steiglitz B. M., Thomas, C. L., Maas, S. A., Takahara, K., Cho, K. W. Y. and Greenspan D. S. Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distribution of expression relevant to patterning and skeletogenesis. Dev. Biol. 213, 283-300 (1999)
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• Scott, I. C., Clark, T. G., Takahara, K., Hoffman, G. G., Eddy, R.L., Haley, L. L., Shows, T. B. and Greenspan, D. S. Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32-q33 and 10q23-24 and assignment of murine Tll2 to chromosome 19. Cytogenet. Cell Genet. 86, 64-65 (1999)
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• Scott, I. C., Clark, T. G., Takahara, K., Hoffman, G. G. and Greenspan, D. S. Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein. Genomics 55, 229-234 (1999)
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• Lee, S., Solow-Cordero, Kessler, E., Takahara, K. and Greenspan, D. S. Transforming growth factor-β regulation of bone morphogenetic protein-1/procollagen C-proteinase and related proteins in fibrogenic cells and keratinocytes. J. Biol. Chem. 272, 19059-19066 (1997)
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• Suzuki, N., Labosky, P. A., Furuta, Y., Hargett, L., Dunn, R., Fogo, A. B., Takahara, K., Peters, D. M. P., Greenspan, D. S. and Hogan, B. L. M. Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by bmp1. A mammalian gene related to drosophila tolloid. Development 122, 3587-3595 (1996)
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• Toriello, H. V., Glover, T.W., Takahara, K., Byers, P. H., Miller, D. E., Higgins, J. V., Glover, T. W. and Greenspan, D. S. A translocation interrupts the COL5A1 gene in a patient with Ehlers-Danlos syndrome and hypomelanosis of Ito. Nature Genet. 13, 361-365 (1996)
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• Kessler, E., Takahara, K., Biniaminov, L., Brusel, M. and Greenspan, D.S. Bone morphogenetic protein-1: type I procollagen C-proteinase. Science 271, 360-362 (1996)
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• Takahara, K., Brevard, R., Hoffman, G.G., Suzuki, N. and Greenspan, D. S. Characterization of a novel gene product (mammalian tolloid-like) with a high degree of sequence similarity to mammalian tolloid/bone morphogenetic protein-1. Genomics 34, 157-165 (1996)
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• Takahara, K.†, Osborne, L.†, Elliot, R.W., Tsui, L-C., Sherer, S.W. and Greenspan, D.S. Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein. Genomics 31, 253-256 (1996) (†equal contribution)
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• Takahara, K., Bong, M., Brevard, R., Eddy, R.L., Haley, L.L., Jani-Sait, S., Shows, T.B., Hoffman, G.G. and Greenspan, D.S. Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L. Genomics 31, 119-122 (1996)
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• Takahara, K., Hoffman, G. G. and Greenspan, D. S. Complete structural organization of the human α1(V) collagen Gene (COL5A1): divergence from the conserved organization of other characterized fibrillar collagen gene. Genomics 29, 588-597 (1995)
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• Takahara, K., Lee, S., Wood, S. and Greenspan, D.S. Structural organization and localization of the human bone morphogenetic protein/mammalian tolloid gene. Genomics 29, 9-15 (1995)
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• Takahara, K., Lyons, G. E. and Greenspan, D. S. Bone morphogenetic protein-1 and mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues. J. Biol. Chem. 269, 32572-32578 (1994)
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• Takahara, K., Kessler, E., Biniaminov, L., Brusel, M., Eddy, R. E., Jani-Saito, S., Shows, T.B. and Greenspan, D. S. Type I procollagen C-protenase enhancer protein: identification, primary structure and chromosomal localization of the cognate human gene (PCOLCE). J. Biol. Chem. 269, 26280-26285 (1994)
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• Takahara, K., Hayashi, N., Fujita-Sagawa, K., Morishita, T., Hashimoto, Y. and Noda, A. Alternative splicing of bovine terminal deoxynucleotidyl transferase cDNA. Biosci. Biotech. Biochem. 58, 786-787 (1994)
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• Hatai, M., Takahara, K., Hashi, H., Kato, I. and Yaoi, Y. Effects of fibronectin-type V collagen recombinant fusion protein on cell adhesion and cell proliferation. Cell Struct. Funct. 17, 293-300 (1992)
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• Nakamura, N., Sugino, H., Takahara, K., Jin, C. and Matsubara, K. Endogenous retroviral LTR DNA sequences as markers for individual human chromosomes. Cytogenet. Cell Genet. 57, 18-22 (1991)
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• Takahara, K., Sato, Y., Okazawa, K., Okamoto, N., Noda, A., Yaoi, Y. and Kato, I. Complete primary structure of human collagen α1(V) chain. J. Biol. Chem. 266, 13124-13129 (1991)
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• Yaoi, Y., Hashimoto, K., Takahara, K. and Kato, I. Insulin binds to type V collagen with retention of mitogenic activity. Exp. Cell Res. 194, 180-185 (1991)
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• Shiosaki, K., Miyatsu, Y., Takahara, K., Mizokami, H., Hamada, F. and Matsubara, K. A yeast system for stable expression of hepatitis B surface antigen. J. Biotechnol. 14, 411-422 (1990)
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• Yaoi, Y., Hashimoto, K., Koitabashi, H., Takahara, K., Ito, M. and Kato, I. Primary structure of the heparin-binding site of type V collagen. Biochim. Biophys. Acta 1035, 139-145 (1990)
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• Takahara, K., Fukushige, S., Murotsu, T., Ichihara, Y., Hayano, T., Ishihara, T., Takahashi, K. and Matsubara, K. Assignment of human pepsinogen C (PGC) gene to chromosome 6. Cytogenet. Cell Genet. 52, 100-101 (1989)
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○総説
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• 高原 和彦. C-型レクチンによる生体応答制御 -恒常性の維持と応用—. 臨床免疫・アレルギー科. 66, 115-121 (2016)
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• 足立 匠、高原 和彦、稲葉 カヨ. 微細粒子物質による炎症惹起. 臨床免疫・アレルギー科. 60, 589-595 (2013)
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• 高原 和彦、石黒 俊史. C-型レクチンDC-SIGNを介したIL-10産生と免疫制御. 臨床免疫・アレルギー科. 60, 603-610 (2013)
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• 樹状細胞に発現するCタイプレクチンDCIR（Dendritic cell immunoreceptor）の機能と生体における働き. 臨床免疫・アレルギー科. 52, 11-18 (2009)
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• 高原 和彦、長岡 孝治、稲葉 カヨ. 樹状細胞に発現するC型レクチンの機能とシグナル伝達. 実験医学. 26, 3187-3196 (2008)
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• 長岡 孝治、武田 達樹、高原 和彦. マウスC型レクチンSIGNR1とその免疫応答 における役割. 臨床免疫. 45, 259-265 (2006)
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• 高原 和彦、長岡 孝治、吉田 英雄. 樹状細胞上のC-タイプレクチン群とそのリガンド. 臨床免疫. 43, 189-196 (2005)
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• 高原 和彦. 樹状細胞におけるパターン認識レセプターとしてのレクチン. 臨床免疫. 40, 117-125 (2003)
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• 高原 和彦、稲葉 カヨ. 樹状細胞による免役寛容の誘導と維持. 細胞工学. 21, 1294-1297 (2002)
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• 高原 和彦、稲葉 カヨ. 樹状細胞の抗原プロセッシングと腫瘍免疫. 医学のあゆみ. 194, 1216-1221, 2000
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• 高原 和彦、玉城 征郎、稲葉 カヨ. 樹状細胞による抗原ペプチドの提示とその腫瘍免疫への応用. 現代医療. 32, 1139-1145 (2000)
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• 高原 和彦、玉城 征郎、稲葉 カヨ. 抗腫瘍免疫療法における樹状細胞. 最新医学. 54, 240-247 (1999)
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• 高原 和彦、稲葉 カヨ. 生体防御における樹状細胞の役割と応用. バイオサイエンスとインダストリー. 56, 450-455 (1998)
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• 高原 和彦. BMP-1とI型プロコラーゲンC-プロテイナーゼ. 実験医学. 14, 1872-1875 (1996)
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• 福重 真一、中村 紀彦、高原 和彦、吉村 俊一、室津 知明. ヒト染色体のソーティング. 細胞工学. 7, 896-903 (1988)
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○特許
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• 特開平02-209899 インスリン結合活性を有するポリペプチド
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• 特開平04-054199 機能性ポリペプチド
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• 特開平04-074200 機能性ポリペプチド
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• 特開平05-097698 機能性ポリペプチド
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• 特開平06-105687 ヒトコラーゲンＶ型遺伝子
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• 特開平07-039378 逆転写酵素遺伝子
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• 特開平11-092396 インスリン結合阻害剤
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• 特開平11-092404 インスリン結合用担体
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• US Issued Patent No. 5939321 Mammalian Tolloid-Like Gene and Protein.
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