| • Sudo K., Todoroki T., Ka Y., and Takahara K., Vg5Vd1 TCR signaling is required to different extents for embryonic versus postnatal development of DETCs. Int. Immunol., 34, 263–276 (2022). (Selected as Featured article of the month/Editor's Choice, and Highlights from International Immunology in 2022)
|
• Kawakita M., Oyama T., Shirai I., Tanaka S., Akaki K., Abe S., Asahi T, Cui G., Itoh F., Sasaki M., Shibata N., Ikuta K., Hatakeyama T. and Takahara K., Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis. Commun. Biol. DOI: 10.1038/s42003-021-01870-3 (2021).
|
• Cui G., Shimba A., Ma G, Takahara K., Tani-ichi S., Zhu Y., Asahi T., Abe A., Miyachi H., Kitano S., Hara T., Yasunaga J., Suwanai H., Yamada H., Matsuoka M., Ueki K., Yoshikai Y, and Ikuta K. IL-7R-dependent Phosphatidylinositol-3 Kinase Competes with STAT5 Signal to Modulate T Cell Development and Homeostasis. J. Immunol. 204, 844-57 (2020).
|
• Goji, T., Takahara, K., Negishi, M. and Katoh, H. Glucose metabolism in glioblastoma cells protects against cell death triggered by cystine uptake through xCT. J. Biol. Chem. 292, 19721–19732 (2017).
|
• Ishiguro, T.†, Fukawa, T.†, Akaki, K., Nagaoka, K., Takeda, T., Iwakura, Y., Inaba, K., and Takahara, K. Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice. Eur. J. Immunol. 47, 704-12 (2017) (†equal contribution)
|
• Tokieda, S., Komori, M., Ishiguro, Iwakura, Y., Takahara, K.* and Inaba, K. Dendritic cell immunoreceptor 1 alters neutrophil responses in the development of experimental colitis. BMC Immunol. 16, 64 (2015) (*corresponding author)
|
• Ushida, M., Iyoda, T., Kanamori, M., Watarai, H., Takahara, K.* and Inaba, K. In vivo and in vitro analyses of α-galactosylceramide uptake by conventional dendritic cell subsets using its fluorescence-labeled derivative. Immunol. Lett. 168, 300-5 (2015) (*corresponding author)
|
• Taneo, J., Adachi, T, Yoshida, A., Takeyasu, K., Takahara, K.* and Inaba, K. Amyloid β oligomers induce interleukin-1β production in primary microglia in a cathepsin B- and reactive oxygen species-dependent manner. Biochem. Biophys. Res. Commun. 458, 561-7 (2015) (*corresponding author)
|
• Adachi, T., Takahara, K., Taneo, J., Uchiyama, Y. and Inaba, K. Particle size of latex beads dictates IL-1β production mechanism. Plos One 8, e68499 (2013)
|
• Minamino, K., Takahara, K., Adachi, T., Nagaoka, K., Iyoda, T., Taki, S., and Inaba, K. IRF-2 regulates B cell proliferation and antibody production through distinct mechanisms. Int. Immunol. 24, 573-81 (2012)
|
• Takahara, K., Arita, T., Tokieda, S., Shibata, N., Okawa, Y., Tateno, H., Hirabayashi, J. and Inaba, K. Difference in fine specificity to polysaccharides of C. albicans mannoprotein between mouse SIGNR1 and human DC-SIGN. Infect. Immun. 89, 1699-1706 (2012)
|
• Takahara, K., Tokieda, S., Nagaoka, K. and Inaba, K. Efficient capture of C. albicans and zymosan by SIGNR1 facilitates TLR2-dependent TNF-α production by macrophages. Int. Immunol. 24, 89-96 (2012)
|
• Kobayashi, C., Shiina, T., Tokioka, A., Hattori, Y., Komori, T., Kobayashi-Miura, M., Takizawa, T., Takahara, K., Inaba, K., Inoko, H., Takeya, M., Dranoff, G. and Sugita, M. GM-CSF-independent CD1a expression in epidermal Langerhans cells: evidence from human CD1A genome-transgenic mice. J. Invest. Dermatol. 132, 241-244 (2012)
|
• Takahara, K., Tokieda, S., Nagaoka, K., Takeda, T., Kimura, Y. and Inaba, K. C-type lectin SIGNR1 enhances cellular oxidative burst response against C. albicans in cooperation with Dectin-1. Eur. J. Immunol. 41, 1435-44 (2011)
|
• Nagaoka, K., Takahara, K., Minamino, K., Takeda, T., Yoshida, Y. and Inaba, K. Expression of C-type lectin, SIGNR3, on subsets of dendritic cells, macrophages and monocytes. J. Leukoc. Biol. 88, 913-924 (2010)
|
• Shin, D. M., Yang, C. S., Yuk. J. M., Lee, J. Y., Kim, K. H., Shin, S. J., Takahara, K., Lee, S.J. and Jo, E. K. Mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1. Cell. Microbiol., 10, 1608-1621 (2008)
|
• Nagaoka, K.†, Takahara, K.†, Tanaka, K., Yoshida, H., Steinman, R. M., Saitoh, S., Akashi-Takamura, S., Miyake, K., Kang, Y. S., Park, C. G. and Inaba, K. Association of SIGNR1 with TLR4/MD-2 enhances signal transduction by recognition of LPS in Gram-negative bacteria. Int. Immunol. 17, 827-836 (2005) (†equal contribution).
|
• Takahara, K.†, Yashima, Y.†, Yoshida, H, Kimura, Y, Kang, Y.-S., Steinman, R. M., Park, C. G. and Inaba, K. Functional comparison of the mouse DC-SIGN, SIGNR1, SIGNR3 and Langerin, C-type lectins. Int. Immunol. 16, 819-829 (2004) (†equal contribution).
|
• Ichikawa, E., Hida, S., Omatsu, Y., Shimoyama, S., Takahara, K., Miyagawa. S., Inaba, K. and Taki, S. Defective development of splenic and epidermal CD4+ dendritic cells in mice deficient for IFN regulatory factor-2. Proc. Natl. Acad. Sci. U.S.A. 101, 3909-3914 (2004)
|
• Wang, W. -M., Lee, S., Steiglitz, B. M., Scott, I. C., Lebares, C.C., Allen, L, Brenner, M. C., Takahara, K. and Greenspan, D. S. Transforming growth factor-β induces secretion of activated ADAMTS-2: A procollagen III N-proteinase. J. Biol. Chem. 278, 19549-19557 (2003)
|
• Kang, Y.-S.†, Yamazaki, S.†, Iyoda, T.†, Pack, M., Bruening, S. A., Kim, J. Y., Takahara, K., Inaba, K., Steinman, R. M. and Park, C. G. SIGN-R1, a novel C-type lectin expressed by marginal zone macrophages in spleen, mediates uptake of the polysaccharide dextran. Int. Immunol. 15, 177-186 (2003) (†equal contribution).
|
• Ichioka, N., Inaba, M., Kushida, T., Esumi, T., Takahara, K., Inaba., K., Ogawa, R., Iida, H. and Ikehara, S. Prevention of senile osteoporosis in SAMP6 mice by intra-bone marrow injection of allogeneic bone marrow cells. Stem Cells 20, 542-551 (2002)
|
• Takahara, K.†, Schwarze, U.†, Imamura, Y., Hoffman, G. G., Toriello, H., Smith, L. T., Byers, P. H. and Greenspan, D. S. Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor site mutation that results in abnormal pro-α1(V) N-propeptides and Ehlers-Danlos syndrome type I. Amer. J. Human Genetics 71, 451-465 (2002) (†equal contribution)
|
• Iyoda, T., Shimoyama, S., Liu, K., Omatsu, Y., Akiyama, Y., Maeda, Y., Takahara, K., Steinman,R. M. and Inaba. K. The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo. J. Exp. Med. 195, 1289-1302 (2002)
|
• Ligon, A. H., Scott, I. C., Takahara, K., Greenspan, D. S. and Morton, C. C. PCOLCE deletion and expression analysis in uterine leiomyomata. Cancer Genet. Cytogenet. 137, 133-137 (2002)
|
•Takahara, K., Omatsu, Y, Yashima, Y., Yasuhiro, M., Tanaka, S., Iyoda, T., Clausen, B., Matsubara, K., Letterio, J., Steinman, R. M., Matsuda, Y. and Inaba, K. Identification and expression of mouse Langerin (CD207) in dendritic cells. Int. Immunol. 14, 433-444 (2002)
|
•Park, C. G.†, Takahara, K.†, Umemoto, E., Yashima, Y., Matsubara, K., Matsuda, Y., Clausen, B. E., Inaba, K. and Steinman, R. M. Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN. Int. Immunol. 13, 1283-1290 (2001) (†equal contribution)
|
• Komuro, H., Mori, M., Hayashi, Y., Fukagawa, M., Makino, S., Takahara, K., Greenspan, D. S. and Momoi, M. Lack of BMP-1 gene mutations in patient with gastroschisis. J. Pediatric Surgery 36, 885-887 (2001)
|
• Amano, S., Scott , I. C., Takahara, K., Koch, M., Gerecke, D. R., Keene, D. R., Hudson, D. L., Nishiyama, T., Lee, S., Greenspan, D. S. and Burgeson R. E. Bone morphogenetic protein 1 (BMP-1) is an extracellular processing enzyme of the laminin 5γ2 chain. J. Biol. Chem. 275, 22728 -22735 (2000)
|
• Mott, J. D., Thomas, C. L., Rosenbach, M. T., Takahara, K., Greenspan, D. S. and Banda, M. J. Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer release a metalloproteinase inhibitor. J. Biol. Chem. 275, 1384-1390 (2000)
|
• Scott, I. C., Blitz, I. L., Pappano, W. N., Imamura, Y., Clark, T. G., Steiglitz B. M., Thomas, C. L., Maas, S. A., Takahara, K., Cho, K. W. Y. and Greenspan D. S. Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distribution of expression relevant to patterning and skeletogenesis. Dev. Biol. 213, 283-300 (1999)
|
• Scott, I. C., Clark, T. G., Takahara, K., Hoffman, G. G., Eddy, R.L., Haley, L. L., Shows, T. B. and Greenspan, D. S. Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32-q33 and 10q23-24 and assignment of murine Tll2 to chromosome 19. Cytogenet. Cell Genet. 86, 64-65 (1999)
|
• Scott, I. C., Clark, T. G., Takahara, K., Hoffman, G. G. and Greenspan, D. S. Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein. Genomics 55, 229-234 (1999)
|
• Lee, S., Solow-Cordero, Kessler, E., Takahara, K. and Greenspan, D. S. Transforming growth factor-β regulation of bone morphogenetic protein-1/procollagen C-proteinase and related proteins in fibrogenic cells and keratinocytes. J. Biol. Chem. 272, 19059-19066 (1997)
|
• Suzuki, N., Labosky, P. A., Furuta, Y., Hargett, L., Dunn, R., Fogo, A. B., Takahara, K., Peters, D. M. P., Greenspan, D. S. and Hogan, B. L. M. Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by bmp1. A mammalian gene related to drosophila tolloid. Development 122, 3587-3595 (1996)
|
• Toriello, H. V., Glover, T.W., Takahara, K., Byers, P. H., Miller, D. E., Higgins, J. V., Glover, T. W. and Greenspan, D. S. A translocation interrupts the COL5A1 gene in a patient with Ehlers-Danlos syndrome and hypomelanosis of Ito. Nature Genet. 13, 361-365 (1996)
|
• Kessler, E., Takahara, K., Biniaminov, L., Brusel, M. and Greenspan, D.S. Bone morphogenetic protein-1: type I procollagen C-proteinase. Science 271, 360-362 (1996)
|
• Takahara, K., Brevard, R., Hoffman, G.G., Suzuki, N. and Greenspan, D. S. Characterization of a novel gene product (mammalian tolloid-like) with a high degree of sequence similarity to mammalian tolloid/bone morphogenetic protein-1. Genomics 34, 157-165 (1996)
|
• Takahara, K.†, Osborne, L.†, Elliot, R.W., Tsui, L-C., Sherer, S.W. and Greenspan, D.S. Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein. Genomics 31, 253-256 (1996) (†equal contribution)
|
• Takahara, K., Bong, M., Brevard, R., Eddy, R.L., Haley, L.L., Jani-Sait, S., Shows, T.B., Hoffman, G.G. and Greenspan, D.S. Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L. Genomics 31, 119-122 (1996)
|
• Takahara, K., Hoffman, G. G. and Greenspan, D. S. Complete structural organization of the human α1(V) collagen Gene (COL5A1): divergence from the conserved organization of other characterized fibrillar collagen gene. Genomics 29, 588-597 (1995)
|
• Takahara, K., Lee, S., Wood, S. and Greenspan, D.S. Structural organization and localization of the human bone morphogenetic protein/mammalian tolloid gene. Genomics 29, 9-15 (1995)
|
• Takahara, K., Lyons, G. E. and Greenspan, D. S. Bone morphogenetic protein-1 and mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues. J. Biol. Chem. 269, 32572-32578 (1994)
|
• Takahara, K., Kessler, E., Biniaminov, L., Brusel, M., Eddy, R. E., Jani-Saito, S., Shows, T.B. and Greenspan, D. S. Type I procollagen C-protenase enhancer protein: identification, primary structure and chromosomal localization of the cognate human gene (PCOLCE). J. Biol. Chem. 269, 26280-26285 (1994)
|
• Takahara, K., Hayashi, N., Fujita-Sagawa, K., Morishita, T., Hashimoto, Y. and Noda, A. Alternative splicing of bovine terminal deoxynucleotidyl transferase cDNA. Biosci. Biotech. Biochem. 58, 786-787 (1994)
|
• Hatai, M., Takahara, K., Hashi, H., Kato, I. and Yaoi, Y. Effects of fibronectin-type V collagen recombinant fusion protein on cell adhesion and cell proliferation. Cell Struct. Funct. 17, 293-300 (1992)
|
• Nakamura, N., Sugino, H., Takahara, K., Jin, C. and Matsubara, K. Endogenous retroviral LTR DNA sequences as markers for individual human chromosomes. Cytogenet. Cell Genet. 57, 18-22 (1991)
|
• Takahara, K., Sato, Y., Okazawa, K., Okamoto, N., Noda, A., Yaoi, Y. and Kato, I. Complete primary structure of human collagen α1(V) chain. J. Biol. Chem. 266, 13124-13129 (1991)
|
• Yaoi, Y., Hashimoto, K., Takahara, K. and Kato, I. Insulin binds to type V collagen with retention of mitogenic activity. Exp. Cell Res. 194, 180-185 (1991)
|
• Shiosaki, K., Miyatsu, Y., Takahara, K., Mizokami, H., Hamada, F. and Matsubara, K. A yeast system for stable expression of hepatitis B surface antigen. J. Biotechnol. 14, 411-422 (1990)
|
• Yaoi, Y., Hashimoto, K., Koitabashi, H., Takahara, K., Ito, M. and Kato, I. Primary structure of the heparin-binding site of type V collagen. Biochim. Biophys. Acta 1035, 139-145 (1990)
|
• Takahara, K., Fukushige, S., Murotsu, T., Ichihara, Y., Hayano, T., Ishihara, T., Takahashi, K. and Matsubara, K. Assignment of human pepsinogen C (PGC) gene to chromosome 6. Cytogenet. Cell Genet. 52, 100-101 (1989)
|
○総説
|
• 高原 和彦. C-型レクチンによる生体応答制御 -恒常性の維持と応用—. 臨床免疫・アレルギー科. 66, 115-121 (2016)
|
• 足立 匠、高原 和彦、稲葉 カヨ. 微細粒子物質による炎症惹起. 臨床免疫・アレルギー科. 60, 589-595 (2013)
|
• 高原 和彦、石黒 俊史. C-型レクチンDC-SIGNを介したIL-10産生と免疫制御. 臨床免疫・アレルギー科. 60, 603-610 (2013)
|
• 樹状細胞に発現するCタイプレクチンDCIR（Dendritic cell immunoreceptor）の機能と生体における働き. 臨床免疫・アレルギー科. 52, 11-18 (2009)
|
• 高原 和彦、長岡 孝治、稲葉 カヨ. 樹状細胞に発現するC型レクチンの機能とシグナル伝達. 実験医学. 26, 3187-3196 (2008)
|
• 長岡 孝治、武田 達樹、高原 和彦. マウスC型レクチンSIGNR1とその免疫応答 における役割. 臨床免疫. 45, 259-265 (2006)
|
• 高原 和彦、長岡 孝治、吉田 英雄. 樹状細胞上のC-タイプレクチン群とそのリガンド. 臨床免疫. 43, 189-196 (2005)
|
• 高原 和彦. 樹状細胞におけるパターン認識レセプターとしてのレクチン. 臨床免疫. 40, 117-125 (2003)
|
• 高原 和彦、稲葉 カヨ. 樹状細胞による免役寛容の誘導と維持. 細胞工学. 21, 1294-1297 (2002)
|
• 高原 和彦、稲葉 カヨ. 樹状細胞の抗原プロセッシングと腫瘍免疫. 医学のあゆみ. 194, 1216-1221, 2000
|
• 高原 和彦、玉城 征郎、稲葉 カヨ. 樹状細胞による抗原ペプチドの提示とその腫瘍免疫への応用. 現代医療. 32, 1139-1145 (2000)
|
• 高原 和彦、玉城 征郎、稲葉 カヨ. 抗腫瘍免疫療法における樹状細胞. 最新医学. 54, 240-247 (1999)
|
• 高原 和彦、稲葉 カヨ. 生体防御における樹状細胞の役割と応用. バイオサイエンスとインダストリー. 56, 450-455 (1998)
|
• 高原 和彦. BMP-1とI型プロコラーゲンC-プロテイナーゼ. 実験医学. 14, 1872-1875 (1996)
|
• 福重 真一、中村 紀彦、高原 和彦、吉村 俊一、室津 知明. ヒト染色体のソーティング. 細胞工学. 7, 896-903 (1988)
|
○特許
|
• 特開平02-209899 インスリン結合活性を有するポリペプチド
|
• 特開平04-054199 機能性ポリペプチド
|
• 特開平04-074200 機能性ポリペプチド
|
• 特開平05-097698 機能性ポリペプチド
|
• 特開平06-105687 ヒトコラーゲンＶ型遺伝子
|
• 特開平07-039378 逆転写酵素遺伝子
|
• 特開平11-092396 インスリン結合阻害剤
|
• 特開平11-092404 インスリン結合用担体
|
• US Issued Patent No. 5939321 Mammalian Tolloid-Like Gene and Protein.
|
|
